The SpreadsheetApp service of Google App Script offers the range.setValues() method to update a single cell or a range of cells inside a Google Spreadsheet. You cannot, however, write data to multiple non-consecutive cells in a Spreadsheet using the setValues() method.

The Google Spreadsheet API, available inside Apps Script project through Advanced Google Services, can update multiple cells in one execution. You can write values in single cells, rows, columns or even a 2d matrix of cells.

function updateGoogleSheet(spreadsheetId) {
  /* Written by Amit Agarwal */
  /* Web: ctrlq.org  Email: amit@labnol.org */

  var data = [
    {
      range: 'Sheet1!A1', // Update single cell
      values: [['A1']],
    },
    {
      range: 'Sheet1!B1:B3', // Update a column
      values: [['B1'], ['B2'], ['B3']],
    },
    {
      range: 'Sheet1!C1:E1', // Update a row
      values: [['C1', 'D1', 'E1']],
    },
    {
      range: 'Sheet1!F1:H2', // Update a 2d range
      values: [
        ['F1', 'F2'],
        ['H1', 'H2'],
      ],
    },
  ];

  var resource = {
    valueInputOption: 'USER_ENTERED',
    data: data,
  };

  Sheets.Spreadsheets.Values.batchUpdate(resource, spreadsheetId);
}